Unemployment Rate in Knox County, ME was 4.50% in February of 2024, according to the United States Federal Reserve. Historically, Unemployment Rate in Knox County, ME reached a record high of 10.50 in April of 2020 and a record low of 1.90 in August of 2000. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in Knox County, ME - last updated from the United States Federal Reserve on May of 2024.