Resident Population in Santa Cruz County, CA was 261.54700 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Santa Cruz County, CA reached a record high of 274.86500 in January of 2017 and a record low of 123.79000 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Santa Cruz County, CA - last updated from the United States Federal Reserve on May of 2024.